产品货号：
Z23659
中文名称：
Perforin/PRF1抗体
英文名称：
Anti-Perforin/PRF1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Perforin/PRF1 Antibody |
| 指标别名 | Cytolysin;FLH2;HPLH2;P1;Perforin;Perforin 1;PFN1;PFP;PRF1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | PRF1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Perforin recombinant protein (Position:E175-W555).Human Perforin shares 68% amino acid (aa) sequence identity with both mouse and rat Perforin. |
| 实际分子量 | 61KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | PRF1,also known as Perforin-1,is a protein that in humans is encoded by the PRF1 gene.It is mapped to 10q22.1.PRF1 is a cytolytic protein found in the granules of Cytotoxic T lymphocytes (CTLs) and NK cells.Upon degranulation,PRF1 inserts itself into the target cell's plasma membrane,forming a pore.The lytic membrane-inserting part of perforin is the MACPF domain.This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria.PRF1 has structural and functional similarities to complement component 9 (C9).Like C9,this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells.This protein is one of the main cytolytic proteins of cytolytic granules,and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis.PRF1 is thought to act by creating holes in the plasma membrane which triggers an influx of calcium and initiates membrane repair mechanisms.These repair mechanisms bring perforin and granzymes into early endosomes. |
| Uniprot ID | P14222 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | perforin 1 (pore forming protein) |
| 蛋白名全称 | Perforin-1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：Perforin/PRF1抗体，Perforin抗体，PRF1多抗，Anti-Perforin/PRF1 Antibody